Anti-arrhythmia

Class	Basic Mechanism	Comments
I	sodium-channel blockade	Reduce phase 0 slope and peak of action potential.
IA	- moderate	Moderate reduction in phase 0 slope; increase APD; increase ERP.
IB	- weak	Small reduction in phase 0 slope; reduce APD; decrease ERP.
IC	- strong	Pronounced reduction in phase 0 slope; no effect on APD or ERP.
II	beta-blockade	Block sympathetic activity; reduce rate and conduction.
III	potassium-channel blockade	Delay repolarization (phase 3) and thereby increase action potential duration and effective refractory period.
IV	calcium-channel blockade	Block L-type calcium-channels; most effective at SA and AV nodes; reduce rate and conduction.

引用自此

Class Ia Procainamide Quinidine Disopyramide	Class II Propranolol Atenolol Nadolol Metoprolol Pindolol Esmolol	Others Bretylium Digoxin Adenosine Phenylephrine Midodrine Fludrocortisone
Class Ib Lidocaine Mexiletine Phenytoin Moricizine	Class III Ibutalide Sotalol Amiodarone
Class 1c Flecainide Propafenone	Class IV Verapamil Diltiazem

Structure heart diseaseàI C

LV dysfunction or CADàIII